High Score/Plague Inc: Evolved

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RANK EPI/PANDEMIC CONFIRMED KILLS ACTIVE DISEASE TYPE
1 Black Death ~150 million 1346–1353 Bubonic plague
2 Spanish flu 20–100 million 1918–1920 Influenza (the flu)
3 Plague of Justinian 15–75 million 541–549 (oldest major outbreak) Bubonic plague
4 HIV/AIDS 42 million 1981–present As self
5 COVID-19 7–28 million 2019–present Coronavirus
6 Third plague pandemic ~13 million 1855–1960 Bubonic plague
7 Cocoliztli Epidemic ~10 million 1545–1548 Unidentified
8 Antonine Plague 5–10 million (factor for falling of the Roman Empire) 165–180 Measles or smallpox
9 Unit 731 experiments 400,000+ 1936-1945 Bubonic plague, anthrax, cholera, smallpox
10 Swine flu 18,449 2009-2010 Influenza (the flu)
11 Ebola 15,000+ 1976-present As self
12 SARS 774 2002-2004 Coronavirus
13 Sverdlovsk anthrax leak 66+ 1979 Anthrax
14 Zika 18 2015-2016 As self
15 Amerithrax 5 2001 Anthrax